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Writer's pictureJan Dipasupil

This is One of Zepbound's Most Common Side Effects. Find Out How to Get Quick Relief.

Zepbound, a weight loss medication developed by Eli Lilly, is FDA-approved for adults who are obese or overweight with related health conditions. It is administered via a weekly injection and should be used in combination with a reduced-calorie diet and increased physical activity for chronic weight management​ (FDA)​.


What is Zepbound?


The medication works by targeting two hormone receptors, GLP-1 and GIP, which help reduce appetite and food intake, making it a dual incretin agonist. In clinical trials, Zepbound has shown significant weight reduction, with the highest dosage leading to an average weight loss of 18% to 22.5% over approximately 72 weeks​​.





Potential side effects of Zepbound include gastrointestinal issues such as nausea and diarrhea, and there are serious warnings about the possibility of thyroid tumors, including thyroid cancer. It is not recommended for individuals with certain genetic conditions or a history of severe allergic reactions to tirzepatide, and it should not be used in combination with other tirzepatide-containing products​ (FDA)​​ (DiaTribe)​.


What are Its Side Effects?






Here's a list of side effects associated with Zepbound:

Common gastrointestinal symptoms:

  • Nausea

  • Diarrhea

  • Vomiting

  • Constipation

  • Abdominal pain


Other frequent issues:

  • Fatigue

  • Hypersensitivity reactions (fever, rash)

  • Injection site reactions

  • Burping

  • Hair loss

  • Gastroesophageal reflux disease


Serious potential risks:

  • Thyroid tumors, including thyroid cancer

  • Severe allergic reactions to tirzepatide

  • Pancreatitis

  • Severe gastrointestinal diseases


What is Nausea in Zepbound Intake?

Nausea is one of the most common side effects experienced by users of Zepbound (tirzepatide), especially during the initial phase of treatment. It arises as part of the body's response to the medication's action on hormone receptors that influence gastric and appetite regulation.


Typically, nausea associated with GLP-1 agonists like Zepbound may decrease over time as the body adjusts to the medication. However, if the nausea is severe or persistent, it is important for patients to consult their healthcare provider to manage this side effect effectively


What are the Top Foods for Zepbound Nausea Relief?





When dealing with nausea related to medications like Zepbound, certain foods can help soothe the stomach and alleviate symptoms. Here are some commonly recommended options:

  • Ginger: Known for its anti-nausea properties, ginger can be consumed in various forms such as ginger tea, ginger ale, or raw ginger slices.

  • Dry or plain foods: Simple, bland foods like crackers, toast, or plain rice are easier on the stomach.

  • Cold foods: Cold or room temperature foods often have less odor, which might be easier to handle when feeling nauseous.

  • Clear liquids: Staying hydrated is crucial, and clear liquids like water, broth, or herbal teas can be soothing.

  • Peppermint: Peppermint tea or sucking on peppermint candies can help reduce nausea symptoms.

  • BRAT diet foods: Bananas, rice, applesauce, and toast are gentle on the stomach and can help reduce the urge to vomit.

These suggestions are typically well-tolerated and might help manage nausea, but it's essential to consult with a healthcare provider for tailored advice, especially when managing side effects from a medication like Zepbound.


Take Control of Your Goals Right Now


Zepbound, developed by Eli Lilly, offers a new option for chronic weight management in adults who are obese or overweight with associated health conditions, administered through weekly injections. While effective in reducing body weight significantly, it comes with potential side effects like nausea, which can often be managed with dietary adjustments involving bland, ginger-based, or cold foods. It is crucial for patients to work closely with healthcare providers to monitor and manage these side effects effectively, ensuring the treatment's benefits outweigh the discomforts


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