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Writer's pictureJan Dipasupil

How to Keep Your Mood in Check While Losing Weight on GLP-1 Medications

Updated: Sep 23


The Surprising Link Between Mood and GLP-1 Weight Loss Medications

Have you started taking GLP-1 medications like Ozempic, Wegovy, or Zepbound and noticed changes in your mood? While these drugs are hailed for their weight loss benefits, their impact on emotional well-being is becoming a topic of interest. For many, these medications not only help them shed pounds but may also influence their mental health. Let’s explore how GLP-1 medications can affect your mood and what you can do to keep feeling great while losing weight.


a smiling woman

How GLP-1 Medications Affect Your Mood


Antidepressant Effects

Research suggests that GLP-1 drugs might have a positive effect on mood. These medications work by interacting with receptors in the brain that influence the release of neurotransmitters like dopamine and serotonin—chemicals responsible for regulating happiness and emotional well-being. This has led experts to believe that some individuals might experience relief from symptoms of anxiety or depression while using GLP-1 medications.


Blood Sugar and Mood Fluctuations

GLP-1 medications help regulate blood sugar levels, but fluctuations in blood sugar can affect mood. Low blood sugar, for example, can lead to irritability or anxiety. This is why experts recommend eating regular, balanced meals and avoiding high-sugar, ultra-processed foods while on GLP-1 medications. Doing so helps maintain stable blood sugar levels, which can keep your mood in check​.


Challenges with Sudden Weight Loss and Mental Health


Social and Emotional Changes

While many expect weight loss to bring happiness, rapid weight loss can sometimes trigger feelings of vulnerability or anxiety. Social and lifestyle changes, body image concerns, or pressure to maintain a new body size can all contribute to increased stress or even symptoms of body dysmorphia. It’s important to recognize that while weight loss can improve physical health, emotional well-being requires attention, too.


Tips for Managing Mood While on GLP-1 Medications


a person injecting medication

Stay Nourished

Due to reduced hunger while on GLP-1 drugs, some individuals may not eat enough, leading to undernourishment, which can negatively impact mood. Be intentional about meeting your calorie and nutrient needs by scheduling regular meals, even when you don’t feel hungry. This can help avoid the low energy and irritability associated with not eating enough​


Incorporate Exercise and Sleep

Exercise and good sleep are vital for mood regulation. Regular physical activity releases endorphins, which naturally boost your mood, while adequate sleep supports emotional resilience. Incorporating both into your routine while on GLP-1 medications can help mitigate mood fluctuations​


Seek Support from Healthcare Providers

If you’re experiencing mood changes, don’t hesitate to speak with your healthcare provider. They can help you monitor both your physical and emotional health while on GLP-1 medications, ensuring you’re receiving the best possible care​


Conclusion

While GLP-1 medications like Ozempic, Wegovy, and Zepbound are powerful tools for weight loss, they can also influence your emotional well-being. By staying nourished, practicing self-care, and working closely with your healthcare team, you can maintain a positive outlook while achieving your weight loss goals.

Interested in exploring how GLP-1 medications can support your weight loss journey? Contact Jan Medical Group today to learn about our advanced weight management solutions.

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